STEP 2 CK Content Outline

Diseases of the Blood and Blood-forming Organs

Health and Health Maintenance

• Anemia (iron deficiency, vitamin-related, drug-induced, sickle cell)
• Infection(systemic)

Mechanisms of Disease

• Red cell disorders
• Coagulation disorders
• White cell disorders, including leukopenia, agranulocytosis, and neoplasms

Diagnosis

• Anemia, disorders of red cells, hemoglobin, and iron metabolism (eg, blood loss; iron deficiency anemia, nutritional deficiencies; pernicious anemia, other megaloblastic anemias; hemolytic anemia; anemia associated with chronic disease; aplastic anemia, pancytopenia; thalassemia; sickle cell disease; polycythemia vera; hemochromatosis)
• Bleeding disorders, coagulopathies, thrombocytopenia (eg, hemophilia, von Willebrand disease; qualitative and quantitative platelet deficiencies; disseminated intravascular coagulation; hypofibrinogenemia; immune thrombocytopenic purpura; hemolytic-uremic syndrome)
• Neoplastic disorders (eg, Hodgkin disease, non-Hodgkin lymphomas; acute leukemia in children; acute leukemia in adults; chronic leukemic states; mycosis fungoides; multiple myeloma)
• Eosinophilia and reactions to transfusion of blood components (including complications) and leukopenic disorders, agranulocytosis
• Infection (eg, sepsis, malaria, mononucleosis)

Principles of Management
(With emphasis on topics covered in Diagnosis)

• Pharmacotherapy only
• Management decision (treatment/diagnosis steps)
• Treatment only